Funded Project Details - FY2021
|Title:|| Colon cancer nanotherapy targeting STRAP|
|Congressional District Code:
||Biomedical Laboratory R&D
|| January 2021 -
|FY 2021 Funding Amount:
|Total Award Amount
View full abstract and other project information on NIH RePORTER
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Although activation of the Ras/Raf/MEK/ERK pathway is involved in cell growth, inhibition of apoptosis, induction in stem-like phenotype, and drug resistance, little is known about its dynamic control and plasticity. Recent studies have suggested that the functional crosstalk between APC/Wnt/ß-catenin and RAS-ERK pathways plays an important role in colorectal cancer (CRC) progression and metastasis. Our initial data suggest that the MEK/ERK pathway and subsequently Wnt/ß-catenin signaling are ac...
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