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Funded Project Details - FY2021

Project Number:

Title: The Aquaporin-3/Phospholipase D2 Signaling Pathway in Corneal Wound Healing
Principal Investigator:

Wendy B. Bollag

Location: Augusta, GA
Congressional District Code: 10
Research Service: Biomedical Laboratory R&D
Project Period: July 2020 - June 2024
FY 2021 Funding Amount: $170,312
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Project Summary/Abstract Previous data from our laboratory indicate that the lipid-metabolizing enzyme phospholipase D2 (PLD2) and the glycerol transporter aquaporin-3 (AQP3) physically and functionally interact in epidermal keratinocytes. AQP3 transports glycerol into the cell, making it available to the associated PLD2, which converts it to phosphatidylglycerol (PG). Our results further demonstrate that PG acts as a lipid second messenger to promote epidermal wound healing. Verkman and collea...

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