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Funded Project Details - FY2021

Project Number:

Title: CMA: Network plasticity in acquired epileptogenesis
Principal Investigator:

Stelios Smirnakis

Location: Boston, MA
Congressional District Code: 7
Research Service: Biomedical Laboratory R&D
Project Period: January 2021 - December 2024
FY 2021 Funding Amount: $167,573
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Project Summary/ Abstract: Temporal Lobe Epilepsy (TLE) is the most frequent type of post-­traumatic  epilepsy, causing significant morbidity in the veteran population. Approximately 60% of adult epilepsy cases  are due to TLE, which is often medication-­resistant requiring surgery. Even after surgery, ~30% of patients  continue to have ictal events. TLE causes cognitive deficits, including significant executive, memory, and  neuropsychiatric dysfunction. After initiation by a precipitating even...

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