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Funded Project Details - FY2021

Project Number:

Title: BLR&D Research Career Scientist Award Application
Principal Investigator:

Ann Richmond

Location: Nashville, TN
Congressional District Code: 5
Research Service: Biomedical Laboratory R&D
Project Period: April 2020 - March 2027
FY 2021 Funding Amount: $187,864
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Abstract: Currently, therapeutic treatment with immune checkpoint inhibitors(ICI’s), such as α-CTLA4 and/or α-PD1, are increasing survival rates (>50% four-year survival), particularly in highly mutated tumors. Moreover, combining ICIs with therapies that target tumor oncogenes has been highly effective in some tumors. Our hypothesis is that response to ICI therapy in immunologically “cold” tumors can be enhanced by combining ICIs with therapies targeted to oncogenic drivers that also induce exp...

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