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Project Number: | I01CX001891-05A2 |
| Title: | Natural Killer Cell Subpopulations in COPD Exacerbations |
| Principal Investigator: | Michael T Borchers |
| Location: | Cincinnati, OH |
| Congressional District Code: | 1 |
| Research Service: | Clinical Science R&D |
| Project Period: | October 2020 - September 2024 |
| FY 2023 Funding Amount: | $232,947 |
| Total Award Amount (all years): |
$1,072,869 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Despite decades of research, no effective therapies exist to circumvent the irreversible alterations in lung function associated with COPD. Further, complications of COPD arise from acute and chronic exacerbations that amplify ongoing injury and remodeling that increase morbidity and mortality. The pathophysiology of exacerbations is poorly understood, but is primarily due to inflammation from infections. Some patients are more susceptible to exacerbations and represent an `exacerbator phenotype... |