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Funded Project Details - FY2023

Project Number:

Title: Treatment of Veterans with Heart Failure with Reduced Ejection Fraction with Probenecid
Principal Investigator:

Jack Rubinstein

Location: Cincinnati, OH
Congressional District Code: 1
Research Service: Clinical Science R&D
Project Period: January 2021 - December 2025
FY 2023 Funding Amount: $616,743
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Heart failure with reduced ejection fraction (HFrEF) is a common cause for admission within the Veterans Affairs (VA) Health Care System. It is associated with severe impairment of physical and mental health status, and carries a high 5-yr mortality rate of ~75%. Even though significant progress has been made in understanding its pathophysiology, currently, its management and treatment is based on therapeutic targeting of a limited number of receptors and pathways. Our team and others have made...

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