Talk to the Veterans Crisis Line now
U.S. flag
An official website of the United States government
ORD only    All VA Research websites

Office of Research & Development

print icon sign up for VA Research updates

Funded Project Details - FY2021

Project Number:

Title: Effect of simvastatin on hepatic decompensation and death in subjects with high-risk compensated cirrhosis
Principal Investigator:

David E. Kaplan

Location: Philadelphia, PA
Congressional District Code: 3
Research Service: Clinical Science R&D
Project Period: September 2020 - October 2025
FY 2021 Funding Amount: $1,242,101
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Background: Cirrhosis is the final common pathway of hepatic inflammation and fibrosis caused most commonly by alcohol or viral infection with hepatitis C and/or B. HMG-coA reductase inhibitors (statins) are thought to be beneficial in liver disease by ameliorating intrahepatic endothelial dysfunction, inflammation and fibrosis, thereby leading to a reduction in portal pressure. Because clinically significant portal hypertension is the main driver of decompensation, a reduction in portal pressur...

Questions about the R&D website? Email the Web Team.

Any health information on this website is strictly for informational purposes and is not intended as medical advice. It should not be used to diagnose or treat any condition.