Office of Research & Development |
![]() ![]() |
Project Number: | I01CX002010-01A1 |
Title: | Effect of simvastatin on hepatic decompensation and death in subjects with high-risk compensated cirrhosis |
Principal Investigator: | David E. Kaplan |
Location: | Philadelphia, PA |
Congressional District Code: | 3 |
Research Service: | Clinical Science R&D |
Project Period: | September 2020 - October 2025 |
FY 2021 Funding Amount: | $1,242,101 |
Total Award Amount (all years): |
$6,146,707 |
Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Background: Cirrhosis is the final common pathway of hepatic inflammation and fibrosis caused most commonly by alcohol or viral infection with hepatitis C and/or B. HMG-coA reductase inhibitors (statins) are thought to be beneficial in liver disease by ameliorating intrahepatic endothelial dysfunction, inflammation and fibrosis, thereby leading to a reduction in portal pressure. Because clinically significant portal hypertension is the main driver of decompensation, a reduction in portal pressur... |