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Project Number: | I01CX002010-01A1 |
| Title: | Effect of simvastatin on hepatic decompensation and death in subjects with high-risk compensated cirrhosis |
| Principal Investigator: | David E. Kaplan |
| Location: | Philadelphia, PA |
| Congressional District Code: | 3 |
| Research Service: | Clinical Science R&D |
| Project Period: | September 2020 - October 2025 |
| FY 2021 Funding Amount: | $1,242,101 |
| Total Award Amount (all years): |
$6,146,707 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Background: Cirrhosis is the final common pathway of hepatic inflammation and fibrosis caused most commonly by alcohol or viral infection with hepatitis C and/or B. HMG-coA reductase inhibitors (statins) are thought to be beneficial in liver disease by ameliorating intrahepatic endothelial dysfunction, inflammation and fibrosis, thereby leading to a reduction in portal pressure. Because clinically significant portal hypertension is the main driver of decompensation, a reduction in portal pressur... |