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Funded Project Details - FY2021




Project Number:

I01RX003498-01
Title: Chronic Focal and Diffuse Traumatic Brain Injury: Mechanisms Underlying Epileptogenesis and Progressive Dysfunction
Principal Investigator:

John A Wolf

Location: Philadelphia, PA
Congressional District Code: 3
Research Service: Rehabilitation R&D
Project Period: August 2020 - July 2024
FY 2021 Funding Amount: $567,886
Total Award Amount
(all years):
$1,509,390
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Military traumatic brain injury (TBI) is complex, often involving both diffuse and multi-focal components, and/or repetitive TBI. While the high incidence of epilepsy following TBI in Veterans is well known, PTE is often resistant to standard anti-epileptic therapeutics. In addition, the mechanisms underlying the transition from trauma to injury are unclear, making new treatment development challenging. However, the long gestation period between injury and seizure development (epileptogenesis) m...



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