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Funded Project Details - FY2021

Project Number:

Title: Exercise and pharmacological LRRK2 inhibition for preventing PD
Principal Investigator:

Vedad Delic

Location: East Orange, NJ
Congressional District Code: 10
Research Service: Rehabilitation R&D
Project Period: June 2020 - May 2025
FY 2021 Funding Amount: $205,227
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Mild Traumatic Brain Injury (mTBI) results in a 56% higher risk of developing Parkinson’s disease (PD) in U.S. Veterans. PD presents clinically with resting tremors, balance problems, gait instability, and locomotor deficits. Histological hallmarks of PD are spread of alpha synuclein (α-syn) pathology through interconnected brain regions, and selective loss of dopaminergic neurons in the Substantia Nigra pars compacta (SNpc). There is no cure for PD and treatments are only palliative. With OEF/O...

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