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Project Number: | I01BX005107-01A1 |
| Title: | A role and regulation of glucose responsive lipolysis in pancreatic beta cells |
| Principal Investigator: | Yumi Imai |
| Location: | Iowa City, IA |
| Congressional District Code: | 2 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | January 2021 - December 2024 |
| FY 2021 Funding Amount: | $167,600 |
| Total Award Amount (all years): |
$710,000 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: T2D is a major health problem for US veterans that imposes significant physical, financial, and emotional tolls. Thus, there is a strong and urgent need for an effective and widely applicable therapy. Excessive accumulation of lipids in beta cells is considered to contribute to the development of T2D. Experimental data supports that lipid overload activates multiple stress pathways including inflammation, ER stress, oxidative stress, and mitochondrial dysfunction ultimately leading to the loss o... |