Talk to the Veterans Crisis Line now
U.S. flag
An official website of the United States government

Office of Research & Development

print icon sign up for VA Research updates

Funded Project Details - FY2021




Project Number:

I01BX005128-01A1
Title: Role of Pulmonary Osteoclast-Like Cells in Lung Injury
Principal Investigator:

Francis X. McCormack

Location: Cincinnati, OH
Congressional District Code: 1
Research Service: Biomedical Laboratory R&D
Project Period: May 2021 - April 2025
FY 2021 Funding Amount: $114,587
Total Award Amount
(all years):
$705,837
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

This proposal explores the role of a pulmonary osteoclast-like cell (POLC) in asbestos-induced pulmonary fibrosis. We first discovered POLCs while studying pulmonary alveolar microlithiasis (PAM), a rare, autosomal recessive disorder caused by mutations in the epithelial sodium phosphate co-transporter, Npt2b. Phosphate accumulates in the alveolar lining fluid and complexes with calcium to form spherical hydroxyapatite microliths containing bone matrix proteins and surfactant components. Contact...



Questions about the R&D website? Email the Web Team.

Any health information on this website is strictly for informational purposes and is not intended as medical advice. It should not be used to diagnose or treat any condition.