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Funded Project Details - FY2021

Project Number:

Title: Role of Pulmonary Osteoclast-Like Cells in Lung Injury
Principal Investigator:

Francis X. McCormack

Location: Cincinnati, OH
Congressional District Code: 1
Research Service: Biomedical Laboratory R&D
Project Period: May 2021 - April 2025
FY 2021 Funding Amount: $114,587
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


This proposal explores the role of a pulmonary osteoclast-like cell (POLC) in asbestos-induced pulmonary fibrosis. We first discovered POLCs while studying pulmonary alveolar microlithiasis (PAM), a rare, autosomal recessive disorder caused by mutations in the epithelial sodium phosphate co-transporter, Npt2b. Phosphate accumulates in the alveolar lining fluid and complexes with calcium to form spherical hydroxyapatite microliths containing bone matrix proteins and surfactant components. Contact...

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