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Funded Project Details - FY2021




Project Number:

I01BX005066-01A1
Title: Glycolytic signaling of p38gamma in breast cancer
Principal Investigator:

Guan Chen

Location: Milwaukee, WI
Congressional District Code: 4
Research Service: Biomedical Laboratory R&D
Project Period: April 2021 - March 2025
FY 2021 Funding Amount: $123,494
Total Award Amount
(all years):
$1,127,385
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Triple-negative breast cancer (TNBC) does not express estrogen receptor (ER), progesterone receptor (PR) and Her2 as therapeutic targets and consequently has the worst prognosis among all types of breast cancers. Metabolic reprogramming toward aerobic glycolysis (also called the Warburg effect) is a hallmark of cancer, which is further activated in TNBC. Although aerobic glycolysis may be therapeutically targeted, the druggable pathway has not been identified. p38 is a TNBC oncogene and stimula...



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