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Funded Project Details - FY2021




Project Number:

I01BX000893-09A1
Title: Role of M1 Cytokines in the Progression of Chronic Kidney Disease
Principal Investigator:

Steven D. Crowley

Location: Durham, NC
Congressional District Code: 1
Research Service: Biomedical Laboratory R&D
Project Period: January 2021 - December 2024
FY 2021 Funding Amount: $165,000
Total Award Amount
(all years):
$707,400
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Macrophages can have profound effects on the progression of chronic kidney disease (CKD) via the secretion of pro-inflammatory “M1” cytokines including tumor necrosis factor- (TNF) and Interleukin-1 (IL-1). In the previous cycle, we established that the transcription factor Krüppel like factor 4 in macrophages limits kidney damage and fibrosis by suppressing macrophage TNF expression. However, TNF and IL-1 are also produced by renal tubular cells (RTCs), and our preliminary studies have iden...



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