Funded Project Details - FY2021
|Title:|| Role of M1 Cytokines in the Progression of Chronic Kidney Disease|
Steven D. Crowley
|Congressional District Code:
||Biomedical Laboratory R&D
|| January 2021 -
|FY 2021 Funding Amount:
|Total Award Amount
View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER
Macrophages can have profound effects on the progression of chronic kidney disease (CKD) via the secretion of pro-inflammatory “M1” cytokines including tumor necrosis factor- (TNF) and Interleukin-1 (IL-1). In the previous cycle, we established that the transcription factor Krüppel like factor 4 in macrophages limits kidney damage and fibrosis by suppressing macrophage TNF expression. However, TNF and IL-1 are also produced by renal tubular cells (RTCs), and our preliminary studies have iden...
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