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Project Number: | I01BX003284-05A2 |
| Title: | Mechanisms of Ventilatory Adaptations to Chronic Hypercapnia |
| Principal Investigator: | Hubert V. Forster |
| Location: | Milwaukee, WI |
| Congressional District Code: | 4 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | January 2021 - December 2024 |
| FY 2021 Funding Amount: | $246,425 |
| Total Award Amount (all years): |
$1,222,395 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Chronic lung or neuromuscular diseases impair gas exchange leading to chronic hypercapnia (CH). CH is unfortunately common in the Veteran’s Affairs patient population, and is associated with poor long-term prognoses, higher mortality rates and reduced cognitive function. While systemic physiologic adaptations may limit the negative consequences of CH, patients with CH may be predisposed to pathological maladaptive responses to acute-on-chronic exacerbations thereof, especially within CNS network... |