Office of Research & Development |
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Project Number: | I01BX001060-09A2 |
Title: | Pathogenesis and Impact of Islet Amyloid |
Principal Investigator: | Steven E. Kahn |
Location: | Seattle, WA |
Congressional District Code: | 9 |
Research Service: | Biomedical Laboratory R&D |
Project Period: | January 2021 - December 2024 |
FY 2021 Funding Amount: | $167,600 |
Total Award Amount (all years): |
$710,000 |
Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: PROJECT SUMMARY/ABSTRACT Islet amyloid is a pathological characteristic of type 2 diabetes, contributing to the β-cell loss and secretory dysfunction that characterize the disease. The unique peptide constituent of these amyloid deposits is the β- cell secretory product islet amyloid polypeptide (IAPP), which aggregates to form amyloid resulting in β-cell apoptosis. Human IAPP (hIAPP) aggregation is associated with mitochondrial dysfunction and oxidative stress, but the mechanism by which forma... |