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Funded Project Details - FY2021

Project Number:

Title: Pathogenesis and Impact of Islet Amyloid
Principal Investigator:

Steven E. Kahn

Location: Seattle, WA
Congressional District Code: 9
Research Service: Biomedical Laboratory R&D
Project Period: January 2021 - December 2024
FY 2021 Funding Amount: $167,600
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


PROJECT SUMMARY/ABSTRACT Islet amyloid is a pathological characteristic of type 2 diabetes, contributing to the β-cell loss and secretory dysfunction that characterize the disease. The unique peptide constituent of these amyloid deposits is the β- cell secretory product islet amyloid polypeptide (IAPP), which aggregates to form amyloid resulting in β-cell apoptosis. Human IAPP (hIAPP) aggregation is associated with mitochondrial dysfunction and oxidative stress, but the mechanism by which forma...

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