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Project Number: | I01BX001060-09A2 |
| Title: | Pathogenesis and Impact of Islet Amyloid |
| Principal Investigator: | Steven E. Kahn |
| Location: | Seattle, WA |
| Congressional District Code: | 9 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | January 2021 - December 2024 |
| FY 2021 Funding Amount: | $167,600 |
| Total Award Amount (all years): |
$710,000 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: PROJECT SUMMARY/ABSTRACT Islet amyloid is a pathological characteristic of type 2 diabetes, contributing to the β-cell loss and secretory dysfunction that characterize the disease. The unique peptide constituent of these amyloid deposits is the β- cell secretory product islet amyloid polypeptide (IAPP), which aggregates to form amyloid resulting in β-cell apoptosis. Human IAPP (hIAPP) aggregation is associated with mitochondrial dysfunction and oxidative stress, but the mechanism by which forma... |