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Funded Project Details - FY2021

Project Number:

Title: Manipulating a Virulence Switch to Combat Acinetobacter baumannii Infections
Principal Investigator:

Philip N. Rather

Location: Decatur, GA
Congressional District Code: 4
Research Service: Biomedical Laboratory R&D
Project Period: April 2021 - March 2025
FY 2021 Funding Amount: $123,400
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Acinetobacter baumannii is a nosocomial pathogen responsible for an increasing number of infections in VA, civilian and military hospitals. This proposal will extend novel findings in our lab, where work has identified that A. baumannii cells can exist in two subpopulations, one virulent and one avirulent. These subpopulations can rapidly interconvert and we have identified a central regulator of this switch. This TetR-type regulator is encoded by the ABUW_1645 gene and overexpression of this re...

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