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Funded Project Details - FY2021

Project Number:

Title: Developing novel CRISPR/CasX editors to generate a CCR5/null immune system
Principal Investigator:

Alexandra L. Howell

Location: White River Junction, VT
Congressional District Code: 0
Research Service: Biomedical Laboratory R&D
Project Period: January 2021 - December 2024
FY 2021 Funding Amount: $302,180
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


The characterization of CRISPR/Cas as a method to edit genes that contribute to human diseases provides new opportunities for the development of innovative therapeutic approaches. Seven years ago, this bacterial immune system was adapted to cleave specific regions in the human genome. Currently, there are over a dozen clinical trials planned or in process for cancer, genetic disorders and infectious diseases that utilize CRISPR editing. Moreover, gene editing can be used to cleave and potentiall...

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