The role of AMPK and CD36 in breast cancer tumorigenesis and metastasis
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Biomedical Laboratory R&D
April 2021 -
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View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt:
Breast cancer is the most frequently occurring cancer in women. Military women are at increased risk of breast cancer. The mortality and morbidity from breast cancer is due to its metastatic spread. The role of AMPK in tumorigenesis is controversial. Although AMPK inhibition was implicated in promoting tumorigenesis, we showed, several years ago, that AMPK activation is required for tumor cells survival during solid tumor formation. In recent years this assertion was independently corroborated b...