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Funded Project Details - FY2021




Project Number:

I01BX005093-01A1
Title: Pathogenic role of a protein complex of liver origin as regulator of a proinflammatory program that drives hepatic and intestinal injury in alcoholic liver disease
Principal Investigator:

Natalia Nieto

Location: Chicago, IL
Congressional District Code: 7
Research Service: Biomedical Laboratory R&D
Project Period: April 2021 - March 2025
FY 2021 Funding Amount: $146,041
Total Award Amount
(all years):
$1,336,406
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

ABSTRACT Inflammation is a hallmark of alcohol-induced liver injury. Numerous studies established the role of the gut-to- liver axis, but there is limited information on how the liver-to-gut axis contributes to inflammation and injury in alcoholic liver disease. It is unknown whether ethanol-induced sterile damage-associated molecular patterns of liver origin activate a proinflammatory program that, besides being detrimental to the liver, drive intestinal barrier dysfunction, hence creating an a...



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