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Funded Project Details - FY2021




Project Number:

I01BX003232-05
Title: Mechanisms and Therapeutic Targets of SCC Metastasis
Principal Investigator:

Xiao-Jing Wang

Location: Denver, CO
Congressional District Code: 6
Research Service: Biomedical Laboratory R&D
Project Period: July 2021 - June 2025
FY 2021 Funding Amount: $115,614
Total Award Amount
(all years):
$1,257,597
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Squamous cell carcinomas (SCCs) arise from stratified epithelia, the most relevant organ sites in the veteran population are the skin and oral cavity where high exposure to UV irradiation and tobacco carcinogens make the total and high-risk SCCs significantly higher than the civilian population. SCC’s worst outcome is death through metastasis, most commonly in the lung. SCC deaths exceed melanoma deaths due to the high number of SCC cases. The lack of spontaneous SCC lung metastasis models has h...



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