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Funded Project Details - FY2021

Project Number:

Title: Aberrant RBC SNO transport and endothelial adhesion in sepsis
Principal Investigator:

Timothy J. McMahon

Location: Durham, NC
Congressional District Code: 1
Research Service: Biomedical Laboratory R&D
Project Period: April 2021 - March 2025
FY 2021 Funding Amount: $128,392
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


In critically ill patients, anemia is a well-established risk factor for poor outcomes but, paradoxically, liberal RBC transfusion in these patients does not improve outcomes as compared with a restrictive strategy in which patients remain moderately anemic. Changes taking place very early in the storage process may contribute by impairing RBC function. We have identified functional and biochemical changes in the first day of RBC storage that contribute to a proadhesive effect of blood banking....

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