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Funded Project Details - FY2021

Project Number:

Title: Mechanisms of Regulation of Intestinal Cl Absorption in IBD Associated Diarrhea
Principal Investigator:

Pradeep K. Dudeja

Location: Chicago, IL
Congressional District Code: 7
Research Service: Biomedical Laboratory R&D
Project Period: April 2021 - March 2025
FY 2021 Funding Amount: $128,400
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Diarrhea is the hallmark symptom of inflammatory bowel diseases (IBD). Recurring diarrheal episodes not only significantly affect treatment options, but also the quality of life of the US veteran patients with IBD. IBD associated diarrhea results from a decrease in luminal NaCl and water absorption as well as derangements in barrier integrity. Major route of NaCl absorption in the human intestine involves concerted operation of Na+/H+ and Cl-/HCO3- exchangers. SLC26A3 or DRA (Down-Regulated in A...

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