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Funded Project Details - FY2021

Project Number:

Title: Modulation of Junctional Signaling by BVES in Colorectal Carcinoma
Principal Investigator:

Christopher S Williams

Location: Nashville, TN
Congressional District Code: 5
Research Service: Biomedical Laboratory R&D
Project Period: April 2021 - March 2025
FY 2021 Funding Amount: $128,400
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Colorectal cancer (CRC) has a U.S. incidence rate of almost 150,000 cases per year, encompassing over 10% of new cancer diagnoses. In 2016, within the Veterans Administration Healthcare System alone, 3,400 new patients were diagnosed with CRC, including 614 with advanced disease and very limited treatment options. Understanding the basic biology of the underlying malignant transformation is the key to identifying new therapeutic targets and intervention strategies. Epithelial junctional dysfunct...

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