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Funded Project Details - FY2021

Project Number:

Title: Reversing Cigarette Smoke-Induced Antiviral Immunosuppression
Principal Investigator:

Jordan P. Metcalf

Location: Oklahoma City, OK
Congressional District Code: 5
Research Service: Biomedical Laboratory R&D
Project Period: October 2020 - September 2024
FY 2021 Funding Amount: $156,800
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


The long-term goal of our work is to understand how the human innate immune system responds to Influenza A virus (IAV) infection and to find novel methods to control the infection. Cigarette smoking is a significant public health problem, particularly among veterans. Exposure to cigarette smoke (CS) significantly increases the risk for respiratory viral infections. Influenza infection is seven times more common and is much more severe in smokers than nonsmokers. The goal of our proposed studies...

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