Funded Project Details - FY2021
|Title:|| Foxp transcription factors in regulatory T cells|
Jonathan S. Maltzman
||Palo Alto, CA
|Congressional District Code:
||Biomedical Laboratory R&D
|| January 2021 -
|FY 2021 Funding Amount:
|Total Award Amount
View full abstract and other project information on NIH RePORTER
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Regulatory T cells (Tregs) are critical for actively maintaining immune tolerance. The Foxp family of transcription factors is composed of four members; Foxp1, Foxp3 and Foxp4 are expressed in lymphocytes. Foxp family members bind DNA as homo- and hetero-dimers to regulate gene expression. Regulatory T cells are CD4+ T cells that express Foxp3. We have generated mice in which both Foxp1 and Foxp4 are deleted in either all T lymphocytes or in Tregs, leaving Foxp3 the only potentially expressed fa...
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