Funded Project Details - FY2021
|Title:|| Immunoregulation of Myelin Specific T Lymphocytes|
Arthur A. Vandenbark
|Congressional District Code:
||Biomedical Laboratory R&D
|| January 2021 -
|FY 2021 Funding Amount:
|Total Award Amount
View full abstract and other project information on NIH RePORTER
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Multiple sclerosis (MS) is a devastating chronic, demyelinating autoimmune diseases of the central nervous system (CNS). Two key cytokines/chemokines thought to drive the early inflammatory stage of MS to a chronic progressive phase are macrophage Migration Inhibitory Factor (MIF) and its homolog D-Dopachrome Tautomerase (D-DT). Our laboratory designed two potent biological constructs called RTL1000 and a second- generation derivative, DRα1-MOG-35-55, that bind tightly to the MIF receptor, CD74,...
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