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Funded Project Details - FY2021

Project Number:

Title: Immunoregulation of Myelin Specific T Lymphocytes
Principal Investigator:

Arthur A. Vandenbark

Location: Portland, OR
Congressional District Code: 3
Research Service: Biomedical Laboratory R&D
Project Period: January 2021 - December 2024
FY 2021 Funding Amount: $167,600
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Multiple sclerosis (MS) is a devastating chronic, demyelinating autoimmune diseases of the central nervous system (CNS). Two key cytokines/chemokines thought to drive the early inflammatory stage of MS to a chronic progressive phase are macrophage Migration Inhibitory Factor (MIF) and its homolog D-Dopachrome Tautomerase (D-DT). Our laboratory designed two potent biological constructs called RTL1000 and a second- generation derivative, DRĪ±1-MOG-35-55, that bind tightly to the MIF receptor, CD74,...

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