Targeting Innate Immunity as A Therapeutic Intervention for Parkinsons Disease
Congressional District Code:
Biomedical Laboratory R&D
July 2021 -
FY 2021 Funding Amount:
Total Award Amount (all years):
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt:
This proposal is a renewal of our current VA Merit award and is focused on understanding the interactions between innate immune responses and Parkinson’s Disease (PD) pathogenesis. We previously discovered that the neuronal protein, alpha-synuclein (α-syn), protects the brain from viral infections. With our current VA Merit support, we extended these findings to discover that α-syn expression in neurons is required for expression of neuronal interferon stimulated gene (ISG) expression independen...