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Project Number: | I01BX004931-01A2 |
| Title: | CARP-1: A Potential Therapeutic Agent for Breast Cancer |
| Principal Investigator: | Arun Rishi |
| Location: | Allen Park, MI |
| Congressional District Code: | 13 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | April 2021 - March 2025 |
| FY 2021 Funding Amount: | $128,316 |
| Total Award Amount (all years): |
$709,862 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Development of new and improved strategies for triple-negative breast cancer (TNBC) treatment is urgently needed since molecular complexity of TNBC together with therapy-associated side effects and emergence of drug-resistance often limit effectiveness of current therapies. CARP-1/CCAR1 is a ubiquitous, phospho-protein that can induce proliferation and apoptosis through multiple mechanisms. CARP-1 transduces chemotherapy (adriamycin, etoposide, or Iressa)-dependent inhibitory signaling, and co-a... |