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Funded Project Details - FY2021




Project Number:

I01BX004931-01A2
Title: CARP-1: A Potential Therapeutic Agent for Breast Cancer
Principal Investigator:

Arun Rishi

Location: Allen Park, MI
Congressional District Code: 13
Research Service: Biomedical Laboratory R&D
Project Period: April 2021 - March 2025
FY 2021 Funding Amount: $128,316
Total Award Amount
(all years):
$709,862
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Development of new and improved strategies for triple-negative breast cancer (TNBC) treatment is urgently needed since molecular complexity of TNBC together with therapy-associated side effects and emergence of drug-resistance often limit effectiveness of current therapies. CARP-1/CCAR1 is a ubiquitous, phospho-protein that can induce proliferation and apoptosis through multiple mechanisms. CARP-1 transduces chemotherapy (adriamycin, etoposide, or Iressa)-dependent inhibitory signaling, and co-a...



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