Funded Project Details - FY2021
|Title:|| Agnostic Immunization by Immunogenic Cell Death|
John M Jessup
|Congressional District Code:
||Biomedical Laboratory R&D
|| April 2021 -
|FY 2021 Funding Amount:
|Total Award Amount
View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER
Cancer vaccines against defined tumor antigens in solid tumors have not worked well in patients because the host immune response is insufficient to reject established tumor. Adoptive therapy with CAR T cells works in leukemias where the antigens are essential for leukemia growth but solid tumors do not have similar antigens essential for cancer growth. Adoptive therapy with ex vivo expanded immune cells has led to complete responses in solid tumors but the immune responses have been to unanticip...
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