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Funded Project Details - FY2021

Project Number:

Title: Agnostic Immunization by Immunogenic Cell Death
Principal Investigator:

John M Jessup

Location: Washington, DC
Congressional District Code: 98
Research Service: Biomedical Laboratory R&D
Project Period: April 2021 - March 2025
FY 2021 Funding Amount: $97,500
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Cancer vaccines against defined tumor antigens in solid tumors have not worked well in patients because the host immune response is insufficient to reject established tumor. Adoptive therapy with CAR T cells works in leukemias where the antigens are essential for leukemia growth but solid tumors do not have similar antigens essential for cancer growth. Adoptive therapy with ex vivo expanded immune cells has led to complete responses in solid tumors but the immune responses have been to unanticip...

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