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Funded Project Details - FY2021

Project Number:

Title: Macrophage-Mediated Gene Delivery of Neurotrophic Factors in Parkinson's Disease
Principal Investigator:

Senlin Li

Location: San Antonio, TX
Congressional District Code: 21
Research Service: Biomedical Laboratory R&D
Project Period: July 2021 - June 2025
FY 2021 Funding Amount: $74,191
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Abstract The development of a neuroprotective therapy for Parkinson's disease (PD) would be a major therapeutic advance, particularly for our veterans. Glial cell line-derived neurotrophic factor (GDNF) has been shown to be the most potent protective trophic molecule to dopamine (DA) neurons affected in PD. GDNF requires CNS delivery as it does not cross the blood-brain barrier (BBB). Unfortunately, clinical trials of GDNF therapy in PD patients have given mixed results. It is challenging to del...

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