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Funded Project Details - FY2021




Project Number:

I01BX004739-01A2
Title: Optimization and preclinical characterization of anthranilamide derivatives for Alzheimer prevention
Principal Investigator:

William (zhiming) Suo

Location: Kansas City, MO
Congressional District Code: 5
Research Service: Biomedical Laboratory R&D
Project Period: October 2020 - September 2024
FY 2021 Funding Amount: $391,126
Total Award Amount
(all years):
$1,776,630
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Alzheimer's disease (AD) is a devastating dementia without a disease-modifying therapy. According to FDA, AD clinical trials are over 200 but so far have made zero success in slowing AD progression. This continuous failure speaks for the difficulty of this task and calls for re-evaluating the existing therapeutic strategies. As a neurodegenerative disorder, neuronal death is fundamental to AD pathogenesis. Current therapeutic strategies concentrate on combating neurotoxic insults implicated in...



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