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Funded Project Details - FY2021




Project Number:

I01CX002212-01
Title: Effect of Gut Microbiome Dysbiosis in the Pathobiology of Multiple Sclerosis
Principal Investigator:

Ashutosh Mangalam

Location: Iowa City, IA
Congressional District Code: 2
Research Service: Clinical Science R&D
Project Period: January 2021 - December 2024
FY 2021 Funding Amount: $225,999
Total Award Amount
(all years):
$1,200,000
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Despite the association between gut microbiota and multiple sclerosis (MS) being increasingly appreciated, the mechanism through which gut bacteria and their metabolites modulate disease in MS is poorly understood. We and others have shown a link between perturbations in the gut microbiota in MS patients. Gut dysbiosis, a qualitative alteration in healthy gut microbiota is characterized by an increased abundance of inflammation-promoting bacteria (pathobiont) and depletion of beneficial bacteria...



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