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Funded Project Details - FY2021




Project Number:

I01CX002084-01A2
Title: TP-R: a novel mediator of obesity-linked insulin resistance in humans
Principal Investigator:

Saraswathi Viswanathan

Location: Omaha, NE
Congressional District Code: 2
Research Service: Clinical Science R&D
Project Period: April 2021 - March 2025
FY 2021 Funding Amount: $176,721
Total Award Amount
(all years):
$1,209,267
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Thromboxane A2 (TXA2), a pro-inflammatory lipid mediator derived from arachidonic acid, exerts its biological effects via thromboxane-prostanoid receptor (TP-R). However, it is currently unknown whether TP-R can modulate metabolic pathways. Although the adipocytes are mainly involved in the storage of excess triglycerides, emerging evidence suggests that they have an important role in amino acid (AA) metabolism, in particular branched chain AAs; of note, elevated plasma levels of branched chain...



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