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Project Number: | I01CX002084-01A2 |
| Title: | TP-R: a novel mediator of obesity-linked insulin resistance in humans |
| Principal Investigator: | Saraswathi Viswanathan |
| Location: | Omaha, NE |
| Congressional District Code: | 2 |
| Research Service: | Clinical Science R&D |
| Project Period: | April 2021 - March 2025 |
| FY 2021 Funding Amount: | $176,721 |
| Total Award Amount (all years): |
$1,209,267 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Thromboxane A2 (TXA2), a pro-inflammatory lipid mediator derived from arachidonic acid, exerts its biological effects via thromboxane-prostanoid receptor (TP-R). However, it is currently unknown whether TP-R can modulate metabolic pathways. Although the adipocytes are mainly involved in the storage of excess triglycerides, emerging evidence suggests that they have an important role in amino acid (AA) metabolism, in particular branched chain AAs; of note, elevated plasma levels of branched chain... |