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Funded Project Details - FY2021

Project Number:

Title: Discontinuation of levothyroxine therapy for patients with subclinical hypothyroidism: a pilot randomized, double-blinded, placebo-controlled study
Principal Investigator:

Spyridoula Maraka

Location: Little Rock, AR
Congressional District Code: 2
Research Service: Health Services R&D
Project Period: March 2021 - August 2022
FY 2021 Funding Amount: $69,923
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Background: Subclinical hypothyroidism (SCH) is an increasingly common biochemical diagnosis made by finding mildly elevated thyroid stimulating hormone (TSH) yet normal thyroxine levels, affecting up to 200 in 1000 adults, of whom 135 will have nonspecific symptoms and the rest will have no symptoms at all. Following clinical practice guidelines from endocrine societies, SCH is often treated with levothyroxine (LT4). The prevalence of LT4-treated SCH has doubled from 1996 to 2006. More striking...

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