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Funded Project Details - FY2021




Project Number:

I01RX003379-01A2
Title: Caloric restriction promotes sustained neurological recovery after TBI
Principal Investigator:

Bogdan Stoica

Location: Baltimore, MD
Congressional District Code: 7
Research Service: Rehabilitation R&D
Project Period: July 2021 - June 2025
FY 2021 Funding Amount: $74,535
Total Award Amount
(all years):
$1,198,552
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Traumatic brain injury (TBI) results in extensive cellular structural damage followed by widespread dysfunctions in molecular cascades; including maladaptive activation and/or dysregulation of endogenous injury-response mechanisms. These lead to progressive tissue loss and chronic neurological deficits - secondary injury. The maladaptive strong and persistent activation of microglia to a dysfunctional neurotoxic activation phenotype after brain trauma, contributes to progressive neurodegeneratio...



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