Caloric restriction promotes sustained neurological recovery after TBI
Congressional District Code:
July 2021 -
FY 2021 Funding Amount:
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View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt:
Traumatic brain injury (TBI) results in extensive cellular structural damage followed by widespread dysfunctions in molecular cascades; including maladaptive activation and/or dysregulation of endogenous injury-response mechanisms. These lead to progressive tissue loss and chronic neurological deficits - secondary injury. The maladaptive strong and persistent activation of microglia to a dysfunctional neurotoxic activation phenotype after brain trauma, contributes to progressive neurodegeneratio...