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Funded Project Details - FY2021

Project Number:

Title: Novel Functions for Ras family GTPases
Principal Investigator:

John OBryan

Location: Charleston, SC
Congressional District Code: 1
Research Service: Biomedical Laboratory R&D
Project Period: April 2021 - March 2025
FY 2021 Funding Amount: $178,450
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Mutational activation of RAS occurs in approximately 30% of human tumors with some cancers such as pancreatic cancer having RAS mutations in >90% of tumors. Although mutational activation of RAS shifts RAS to the GTP-bound state, a number of oncogenic RAS proteins are characterized by high intrinsic nucleotide dissociation rates. Thus, these RAS mutants, termed “fast-exchange” mutants, transiently release GTP and transit through the nucleotide-free (apo) state. Following on our previous MERIT aw...

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