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Funded Project Details - FY2021

Project Number:

Title: Circadian Rhythms in Neuronal Models of Bipolar Disorder
Principal Investigator:

Michael J McCarthy

Location: San Diego, CA
Congressional District Code: 52
Research Service: Biomedical Laboratory R&D
Project Period: April 2021 - March 2025
FY 2021 Funding Amount: $128,400
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Bipolar disorder (BD) is a psychiatric disorder associated with heritable polygenic risk factors. While clinically heterogeneous, key clinical features of BD include disruptions in daily sleep and activity cycles indicating that circadian rhythm disruption is an important part of the disorder in many patients. Circadian rhythms are determined by molecular clocks comprised of “clock genes” whose expression is regulated by environmental factors such as light and temperature. In recent years, our g...

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