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Project Number: | I01BX005263-01A1 |
| Title: | Development of 3D Printed Synthetic Bone Graft Containing Small Molecules for Sequential Activation of Hedgehog and Hypoxia Signaling for Treatment of Nonunion Fractures |
| Principal Investigator: | Subburaman Mohan |
| Location: | Loma Linda, CA |
| Congressional District Code: | 31 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | July 2021 - June 2025 |
| FY 2021 Funding Amount: | $89,180 |
| Total Award Amount (all years): |
$709,672 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: ABSTRACT Bone injuries are a major health problem. There are 7.9 million bone fractures sustained annually in the U.S. Healing is impaired in about 10% of these fractures with seriously delayed union or non-union, causing morbidity for patients and enormous healthcare costs. While strategies such as bone grafting, synthetic polymers, low intensity pulsed ultrasound and electromagnetic fields, growth factors and cell therapy are currently being used or investigated to promote bone healing, each... |