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Funded Project Details - FY2021

Project Number:

Title: Lysophosphatidic Acid and Cardiovascular Disease Risk
Principal Investigator:

Andrew J. Morris

Location: Lexington, KY
Congressional District Code: 6
Research Service: Biomedical Laboratory R&D
Project Period: April 2021 - March 2025
FY 2021 Funding Amount: $186,787
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Veterans have a higher incidence of cardiovascular disease than the general population. Valvular diseases including Calcific Aortic Valve Disease (CAVD) are a particular concern for the aging Veteran Population. At present, there is no medical therapy to delay or reverse CAVD, and the only treatment is valve replacement for severe aortic valve stenosis. CAVD involves remodeling of the heart valve tissue as a consequence of endothelial injury, immune cell infiltration and myofibroblastic / osteog...

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