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Funded Project Details - FY2021

Project Number:

Title: Muscarinic Receptors Regulate Colon Cancer Stem Cell Function and Invasiveness
Principal Investigator:

Jean-Pierre Raufman

Location: Baltimore, MD
Congressional District Code: 7
Research Service: Biomedical Laboratory R&D
Project Period: July 2021 - June 2025
FY 2021 Funding Amount: $89,200
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


In Veterans, cancers of the colon and rectum rank third in incidence behind those of the prostate and lung; about one-third of Veterans diagnosed with colon cancer will die, primarily from metastatic disease. However, the molecular events underlying the spread of colon cancer remain uncertain and current treatments for advanced disease are limited and provide only transient benefit. More effective, durable treatments are urgently needed. With previous VA Merit support, we found M3 muscarinic rec...

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