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Funded Project Details - FY2021




Project Number:

I01BX005120-01A2
Title: Enhancing FLT3 inhibitor efficacy in acute myeloid leukemia with FLT3-ITD
Principal Investigator:

Maria Baer

Location: Baltimore, MD
Congressional District Code: 7
Research Service: Biomedical Laboratory R&D
Project Period: July 2021 - June 2025
FY 2021 Funding Amount: $47,694
Total Award Amount
(all years):
$668,494
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Acute myeloid leukemia (AML), the common type of acute leukemia in adults, is an important health concern for Veterans due to its high incidence and frequent poor response to treatment. Internal tandem duplication (ITD) of the fms-like tyrosine kinase 3 (FLT3) receptor tyrosine kinase is present in AML cells of 30% of patients and is associated with poor treatment outcomes. FLT3 inhibitors have activity, but responses are limited and transient, with rapid development of resistance occurring by d...



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