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Funded Project Details - FY2021




Project Number:

I01BX001108-09A1
Title: Mechanisms of ER Stress and Neurodegeneration in Amyotrophic Lateral Sclerosis
Principal Investigator:

Eric J. Huang

Location: San Francisco, CA
Congressional District Code: 12
Research Service: Biomedical Laboratory R&D
Project Period: April 2021 - March 2025
FY 2021 Funding Amount: $78,400
Total Award Amount
(all years):
$710,000
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Neurodegenerative diseases are characterized by accumulation of misfolded proteins in disease-specific neural circuits, which disrupts normal neuronal functions, including axonal transport, mitochondrial bioenergetics, gene expression, and synaptic connectivity. In addition, there is compelling evidence that neuroinflammation can also initiate and/or facilitate disease progression. These results support an interconnected mechanism, in which protein misfolding and neuroinflammation synergisticall...



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