Funded Project Details - FY2021
|Title:|| Mechanisms of ER Stress and Neurodegeneration in Amyotrophic Lateral Sclerosis|
Eric J. Huang
||San Francisco, CA
|Congressional District Code:
||Biomedical Laboratory R&D
|| April 2021 -
|FY 2021 Funding Amount:
|Total Award Amount
View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER
Neurodegenerative diseases are characterized by accumulation of misfolded proteins in disease-specific neural circuits, which disrupts normal neuronal functions, including axonal transport, mitochondrial bioenergetics, gene expression, and synaptic connectivity. In addition, there is compelling evidence that neuroinflammation can also initiate and/or facilitate disease progression. These results support an interconnected mechanism, in which protein misfolding and neuroinflammation synergisticall...
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