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Funded Project Details - FY2021

Project Number:

Title: High-dose Testosterone in Men with Metastatic Castration-resistant Prostate Cancer and ATM or CDK12 deficiency
Principal Investigator:

Robert B. Montgomery

Location: Seattle, WA
Congressional District Code: 9
Research Service: Clinical Science R&D
Project Period: April 2021 - March 2026
FY 2021 Funding Amount: $294,975
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Abstract Advanced prostate cancer is a universally lethal disease and one for which no biomarkers have yet been found to inform therapeutic decision making. DNA repair deficiency in the homologous recombination and CDK12 pathways increases sensitivity of tumors to the DNA damaging effects of high dose testosterone based on early biomarker interrogations of phase II high dose testosterone studies. High dose testosterone is also very well tolerated in appropriately selected patient populations who...

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